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(2024) found that Tan IIA combined with osimertinib inhibited sterol regulatory element-binding proteins (SREBPs) signaling, downregulated the expression of SREBP1, fatty acid synthase (FASN), stearoyl-CoA desaturase (SCD), SREBP2, HMGCS1, inhibited SREBP signaling-mediated lipid desaturation and cholesterol synthesis, increased unsaturated lipid levels, decreased glutathione (GSH) levels, and increased ROS levels in osimertinib-resistant H1975/OR cells and reduced cell membrane fluidity, and reversed osimertinib-resistant H1975/OR cells’ resistance to osimertinib in both osimertinib-resistant H1975/OR cell and H1975/OR cell xenograft BALB/c mouse models

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Schfanfelberg 2021)